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Title: Obesity and appetite-related hormones
Authors: Supornpim Chearskul
Suwattanee Kooptiwut
Sudaporn Pummoung
Siriporn Vongsaiyat
Malika Churintaraphan
Namoiy Semprasert
Smarn Onreabroi
Sucheera Phattharayuttawat
Mahidol University
Keywords: Medicine
Issue Date: 29-Nov-2012
Citation: Journal of the Medical Association of Thailand. Vol.95, No.11 (2012), 1472-1479
Abstract: Objective: Alterations of hormones involved in food intake can lead to obesity and related-diseases. The aim of the present study was to measure plasma levels of appetite-related hormones: insulin, leptin, adiponectin, acylated ghrelin, and cortisol in connection with eating behaviors among obese and non-obese women. Material and Method: The present study was performed in 53 non-obese and 33 obese Thai women (BMI < 23 and ≥ 25 kg/m 2 respectively), aged 25 to 45 years. Saliva and fasting blood samples were collected for hormone measurements. Subjects' eating behavior was evaluated using Thai version of the Three-factor eating questionnaire (TFEQ) and their stress status was assessed by the Thai stress test (TST). Results: In comparison to non-obese individuals, obese women showed higher disinhibition eating, plasma glucose, insulin, HOMA insulin resistance index, leptin, and triglyceride levels but lesser plasma adiponectin and HDLC. Lower adiponectin was directly associated with higher disinhibition eating. Plasma leptin related positively to fat mass and insulin resistance but negatively to acylated ghrelin level. The trend towards increased acylated ghrelin after adjusted for age, obesity and eating behaviors was shown in stress women. Conclusion: Increased insulin resistance, high leptin, and reduced adiponectin accompanied with disinhibition eating have been detected in obese women.
ISSN: 01252208
Appears in Collections:Scopus 2011-2015

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