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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/14523
Title: New insights into acquisition, boosting, and longevity of immunity to malaria in pregnant women
Authors: Freya Ji Fowkes
Rose McGready
Nadia J. Cross
Mirja Hommel
Julie A. Simpson
Salenna R. Elliott
Jack S. Richards
Kurt Lackovic
Jacher Viladpai-Nguen
David Narum
Takafumi Tsuboi
Robin F. Anders
François Nosten
James G. Beeson
Burnet Institute
Melbourne School of Population Health
University of Melbourne
Walter and Eliza Hall Institute of Medical Research
La Trobe University
Shoklo Malaria Research Unit
Mahidol University
Nuffield Department of Clinical Medicine
National Institute of Allergy and Infectious Diseases
Ehime University
Keywords: Medicine
Issue Date: 15-Nov-2012
Citation: Journal of Infectious Diseases. Vol.206, No.10 (2012), 1612-1621
Abstract: Background. How antimalarial antibodies are acquired and maintained during pregnancy and boosted after reinfection with Plasmodium falciparum and Plasmodium vivax is unknown.Methods.A nested case-control study of 467 pregnant women (136 Plasmodium-infected cases and 331 uninfected control subjects) in northwestern Thailand was conducted. Antibody levels to P. falciparum and P. vivax merozoite antigens and the pregnancy-specific PfVAR2CSA antigen were determined at enrollment (median 10 weeks gestation) and throughout pregnancy until delivery.Results.Antibodies to P. falciparum and P. vivax were highly variable over time, and maintenance of high levels of antimalarial antibodies involved highly dynamic responses resulting from intermittent exposure to infection. There was evidence of boosting with each successive infection for P. falciparum responses, suggesting the presence of immunological memory. However, the half-lives of Plasmodium antibody responses were relatively short, compared with measles (457 years), and much shorter for merozoite responses (0.8-7.6 years), compared with PfVAR2CSA responses (36-157 years). The longer half-life of antibodies to PfVAR2CSA suggests that antibodies acquired in one pregnancy may be maintained to protect subsequent pregnancies.Conclusions.These findings may have important practical implications for predicting the duration of vaccine-induced responses by candidate antigens and supports the development of malaria vaccines to protect pregnant women. © 2012 The Author.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867716783&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/14523
ISSN: 00221899
Appears in Collections:Scopus 2011-2015

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