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Title: Purification and characterization of anti-HIV-1 protein from Canna indica L. leaves
Authors: Apanchanid Thepouyporn
Chalobon Yoosook
Wongsatit Chuakul
Krit Thirapanmethee
Chanita Napaswad
Chanpen Wiwat
Department of Pharmaceutical Science
Mahidol University
Keywords: Medicine
Issue Date: 5-Nov-2012
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.43, No.5 (2012), 1153-1159
Abstract: A novel 10 kDa protein with anti-HIV-1 reverse transcriptase (RT) inhibitory activity was isolated from leaves of Canna indica L. using a combination of native-PAGE and ammonium sulfate precipitation. HIV-1 and RT inhibitory activity was measured using a syncytium forming ΔTat/Rev MC99 virus in Tat/Rev transfected 1A2 cell line and ELISA technique, respectively. Edman N-terminal and internal amino acid sequence (using LC-MS-MS) determination revealed the 10 kDa Canna indica L. leaf protein as a putative plastocyanin. This is the first report of a plant plastocyanin with HIV-1 RT inhibitory property.
ISSN: 01251562
Appears in Collections:Scopus 2011-2015

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