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Title: Immune response in diarrheal patients and asymptomatic carrier with CS6-producing enterotoxigenic Escherichia coli infection
Authors: Orapim Puiprom
Siriporn Chantaroj
Shigeaki Matsuda
Pathom Sawanpanyalert
Takeshi Honda
Tetsuya Iida
Tooru Taniguchi
Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI)
Thailand Ministry of Public Health
Osaka University
Mahidol University
Keywords: Medicine
Issue Date: 1-Nov-2012
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.43, No.6 (2012), 1452-1460
Abstract: Enterotoxigenic Escherichia coli (ETEC) is one of the major causes of diarrhea in children and travelers in developing countries. ETEC colonization factors (CFs) are virulence determinants considered as protective antigens and major targets for vaccine development against ETEC infections. One of the most prevalent CFs, coli surface antigen 6(CS6), a non-fimbrial polymeric protein consisting of two major subunits, CssA and CssB, is produced by approximately 25-35% of ETEC worldwide. We could isolate only CS6-producing ETEC strains from two diarrheal patients and one asymptomatic carrier, but we could not detect CssA- or CssB-specific antibodies in the feces and blood of two patients convalescing from natural ETEC infection and of an asymptomatic carrier using western blotting. Therefore, in order to protect against infection with CS6-producing ETEC, protective levels of CS6 immunity should be incorporated in any future vaccines against ETEC.
ISSN: 01251562
Appears in Collections:Scopus 2011-2015

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