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Title: Curcuma aeruginosa, a novel botanically derived 5a-reductase inhibitor in the treatment of male-pattern baldness: A multicenter, randomized, double-blind, placebo-controlled study
Authors: Ganniga Pumthong
Pravit Asawanonda
Supenya Varothai
Vorapicha Jariyasethavong
Daranporn Triwongwaranat
Puan Suthipinittharm
Kornkanok Ingkaninan
Pimporn Leelapornpisit
Neti Waranuch
Naresuan University
Chulalongkorn University
Mahidol University
Ubon Rajathanee University
Chiang Mai University
Keywords: Medicine
Issue Date: 1-Oct-2012
Citation: Journal of Dermatological Treatment. Vol.23, No.5 (2012), 385-392
Abstract: Background: Several botanically derived agents are available for the treatment of male-pattern baldness. Objective: The aim of this study was to evaluate the efficacy of 5% hexane extract of Curcuma aeruginosa, a botanically derived inhibitor of 5a-reductase and 5% minoxidil in the treatment of androgenetic alopecia. Methods: Eighty-seven men with androgenetic alopecia (AGA) were randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months. Efficacy was assessed by target area hair count, global photographic review as well as patients' subjective assessments of hair regrowth and hair shedding. Results: There were statistically significant improvements in global photographic review (p < 0.001), subjects' overall assessments of hair regrowth (p = 0.008), and hair shedding (p = 0.004) when the combination formulation was compared with placebo. Similarly, treatment with 5% minoxidil and 5% C. aeruginosa extract also led to some degrees of hair regrowth. There were no serious adverse events during and after the study. Conclusion: In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth. © 2012 Informa Healthcare USA on behalf of Informa UK Ltd.
ISSN: 14711753
Appears in Collections:Scopus 2011-2015

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