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Title: Medical progress: Melioidosis
Authors: W. Joost Wiersinga
Bart J. Currie
Sharon J. Peacock
Academic Medical Centre, University of Amsterdam
Royal Darwin Hospital
Menzies School of Health Research
Mahidol University
University of Cambridge
Keywords: Medicine
Issue Date: 13-Sep-2012
Citation: New England Journal of Medicine. Vol.367, No.11 (2012), 1035-1044
Abstract: MELIOIDOSIS, CAUSED BY THE ENVIRONMENTAL GRAM-NEGATIVE BACILlus Burkholderia pseudomallei, is classically characterized by pneumonia and multiple abscesses, with a mortality rate of up to 40%. It is an important cause of community-acquired sepsis in Southeast Asia and northern Australia. Its known global distribution is expanding, a reflection of improvements in diagnostic microbiology and increasing numbers of cases in travelers and returning military personnel (Fig. 1). 1,2 A locally acquired case of melioidosis was recently described in the United States. 3 B. pseudomallei has been classified by the Centers for Disease Control and Prevention as a category B bioterrorism agent, resulting in increased research and understanding of melioidosis. This review considers recent developments in pathogenesis, diagnostics, and treatment. Copyright © 2012 Massachusetts Medical Society.
ISSN: 15334406
Appears in Collections:Scopus 2011-2015

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