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|Title:||Medical progress: Melioidosis|
|Authors:||W. Joost Wiersinga|
Bart J. Currie
Sharon J. Peacock
Academic Medical Centre, University of Amsterdam
Royal Darwin Hospital
Menzies School of Health Research
University of Cambridge
|Citation:||New England Journal of Medicine. Vol.367, No.11 (2012), 1035-1044|
|Abstract:||MELIOIDOSIS, CAUSED BY THE ENVIRONMENTAL GRAM-NEGATIVE BACILlus Burkholderia pseudomallei, is classically characterized by pneumonia and multiple abscesses, with a mortality rate of up to 40%. It is an important cause of community-acquired sepsis in Southeast Asia and northern Australia. Its known global distribution is expanding, a reflection of improvements in diagnostic microbiology and increasing numbers of cases in travelers and returning military personnel (Fig. 1). 1,2 A locally acquired case of melioidosis was recently described in the United States. 3 B. pseudomallei has been classified by the Centers for Disease Control and Prevention as a category B bioterrorism agent, resulting in increased research and understanding of melioidosis. This review considers recent developments in pathogenesis, diagnostics, and treatment. Copyright © 2012 Massachusetts Medical Society.|
|Appears in Collections:||Scopus 2011-2015|
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