Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChayawee Muangchanen_US
dc.contributor.authorSarah Hardingen_US
dc.contributor.authorSarit Khimdasen_US
dc.contributor.authorAshley Bonneren_US
dc.contributor.authorMurray Baronen_US
dc.contributor.authorJanet Popeen_US
dc.contributor.otherWestern Universityen_US
dc.contributor.otherMcMaster Universityen_US
dc.contributor.otherSir Mortimer B. Davis Jewish General Hospitalen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationArthritis Care and Research. Vol.64, No.9 (2012), 1405-1414en_US
dc.description.abstractObjective This study was performed to determine the prevalence of elevated C-reactive protein (CRP) levels and the significance of CRP in clinical parameters in systemic sclerosis (SSc; scleroderma) patients. Methods Canadian Scleroderma Research Group data were used. Statistical comparisons were made for CRP levels â8 mg/liter versus > 8 mg/liter, early (a;circ3 years from first non-Raynaud's phenomenon symptom) versus late SSc, and diffuse cutaneous SSc (dcSSc) versus limited cutaneous SSc (lcSSc). A survival analysis was analyzed between patients with normal versus elevated CRP levels. Results A total of 1,043 patients (mean ± SD age 55.4 ± 12.1 years, mean ± SD disease duration of 11.0 ± 9.5 years) were analyzed; elevation of CRP level and erythrocyte sedimentation rate (ESR; > 20 mm/hour) occurred in 25.7% and 38.2%, respectively. Mean ± SD baseline CRP level in dcSSc (11.98 ± 25.41 mg/liter) was higher than in lcSSc (8.15 ± 16.09 mg/liter; P = 0.016). SSc patients with an early disease duration had a higher mean ± SD CRP level (12.89 ± 28.13 mg/liter) than those with a late disease duration (8.60 ± 17.06 mg/liter; P = 0.041). Although not consistent in all subsets, CRP was significantly associated (P < 0.01) with ESR, modified Rodnan skin score (MRSS), worse pulmonary function parameters, disease activity, damage, and Health Assessment Questionnaire. CRP level seemed to normalize in many SSc patients ov er time. Total lung capacity < 80% predicted, MRSS, and serum creatinine were predictors of elevated CRP levels in SSc (odds ratio [OR] 2.76 [95% confidence interval (95% CI) 1.73-4.40] , P = 0.0001; OR 1.03 [95% CI 1.01-1.05], P = 0.005; and OR 1.005 [95% CI 1.001-1.010] , P = 0.02, respectively). Survival for patients with elevated CRP levels was less than for patients with normal CRP levels (P = 0.001). Conclusion CRP level is elevated in one-quarter of SSc patients, especially early disease. It is correlated with disease activity, severity, poor pulmonary function, and shorter survival. Copyright © 2012 by the American College of Rheumatology.en_US
dc.rightsMahidol Universityen_US
dc.titleAssociation of C-reactive protein with high disease activity in systemic sclerosis: Results from the Canadian Scleroderma Research Groupen_US
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.