Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: A HuGE review and meta-analysis
Authors: Ammarin Thakkinstian
Mark McEvoy
Usha Chakravarthy
Subhabrata Chakrabarti
Gareth J. McKay
Euijung Ryu
Giuliana Silvestri
Inderjeet Kaur
Peter Francis
Takeshi Iwata
Masakazu Akahori
Astrid Arning
Albert O. Edwards
Johanna M. Seddon
John Attia
Mahidol University
University of Newcastle, Australia
Queen's University Belfast
L.V. Prasad Eye Institute India
Mayo Clinic
OHSU School of Medicine
National Hospital Organization, Japan
Leibniz Institute of Arteriosclerosis Research
University of Oregon
Tufts University School of Medicine
John Hunter Hospital
Keywords: Medicine
Issue Date: 1-Sep-2012
Citation: American Journal of Epidemiology. Vol.176, No.5 (2012), 361-372
Abstract: The authors performed a systematic review of the association of complement component 2(C2)/complement factor B (CFB) gene polymorphisms with age-related macular degeneration (AMD). In total, data from 19 studies published between 2006 and 2011 were pooled for 4 polymorphisms: rs9332739 and rs547154 in the C2 gene and rs4151667 and rs641153 in the CFB gene. Data extraction and assessments for risk of bias were independently performed by 2 reviewers. Allele frequencies and allele and genotypic effects were pooled. Heterogeneity and publication bias were explored. Pooled minor allele frequencies for all 4 SNPs were between 4.7 and 9.6 for all polymorphisms, except for an Indian population in which the C allele at rs9332739 was the major allele. For the C2 polymorphisms, the minor C allele at rs9332739 and the minor T allele at rs547154 carried estimated relative risks (odds ratios) of 0.55 (95 confidence interval (CI): 0.46, 0.65) and 0.47 (95 CI: 0.39, 0.57), respectively. For the CFB polymorphisms, the minor A alleles at rs4151667 and rs614153 carried estimated risks of 0.54 (95 CI: 0.45, 0.64) and 0.41 (95 CI: 0.34, 0.51), respectively. These allele effects contributed to an absolute lowering of the risk of all AMD in Caucasian populations by 2.06.0. This meta-analysis provides a robust estimate of the protective association of C2/CFB with AMD. © 2012 The Author.
ISSN: 14766256
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.