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dc.contributor.authorAmmarin Thakkinstianen_US
dc.contributor.authorMark McEvoyen_US
dc.contributor.authorUsha Chakravarthyen_US
dc.contributor.authorSubhabrata Chakrabartien_US
dc.contributor.authorGareth J. McKayen_US
dc.contributor.authorEuijung Ryuen_US
dc.contributor.authorGiuliana Silvestrien_US
dc.contributor.authorInderjeet Kauren_US
dc.contributor.authorPeter Francisen_US
dc.contributor.authorTakeshi Iwataen_US
dc.contributor.authorMasakazu Akahorien_US
dc.contributor.authorAstrid Arningen_US
dc.contributor.authorAlbert O. Edwardsen_US
dc.contributor.authorJohanna M. Seddonen_US
dc.contributor.authorJohn Attiaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Newcastle, Australiaen_US
dc.contributor.otherQueen's University Belfasten_US
dc.contributor.otherL.V. Prasad Eye Institute Indiaen_US
dc.contributor.otherMayo Clinicen_US
dc.contributor.otherOHSU School of Medicineen_US
dc.contributor.otherNational Hospital Organization, Japanen_US
dc.contributor.otherLeibniz Institute of Arteriosclerosis Researchen_US
dc.contributor.otherUniversity of Oregonen_US
dc.contributor.otherTufts University School of Medicineen_US
dc.contributor.otherJohn Hunter Hospitalen_US
dc.identifier.citationAmerican Journal of Epidemiology. Vol.176, No.5 (2012), 361-372en_US
dc.description.abstractThe authors performed a systematic review of the association of complement component 2(C2)/complement factor B (CFB) gene polymorphisms with age-related macular degeneration (AMD). In total, data from 19 studies published between 2006 and 2011 were pooled for 4 polymorphisms: rs9332739 and rs547154 in the C2 gene and rs4151667 and rs641153 in the CFB gene. Data extraction and assessments for risk of bias were independently performed by 2 reviewers. Allele frequencies and allele and genotypic effects were pooled. Heterogeneity and publication bias were explored. Pooled minor allele frequencies for all 4 SNPs were between 4.7 and 9.6 for all polymorphisms, except for an Indian population in which the C allele at rs9332739 was the major allele. For the C2 polymorphisms, the minor C allele at rs9332739 and the minor T allele at rs547154 carried estimated relative risks (odds ratios) of 0.55 (95 confidence interval (CI): 0.46, 0.65) and 0.47 (95 CI: 0.39, 0.57), respectively. For the CFB polymorphisms, the minor A alleles at rs4151667 and rs614153 carried estimated risks of 0.54 (95 CI: 0.45, 0.64) and 0.41 (95 CI: 0.34, 0.51), respectively. These allele effects contributed to an absolute lowering of the risk of all AMD in Caucasian populations by 2.06.0. This meta-analysis provides a robust estimate of the protective association of C2/CFB with AMD. © 2012 The Author.en_US
dc.rightsMahidol Universityen_US
dc.titleThe association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: A HuGE review and meta-analysisen_US
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