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Title: Adult-onset immunodeficiency in Thailand and Taiwan
Authors: Sarah K. Browne
Peter D. Burbelo
Ploenchan Chetchotisakd
Yupin Suputtamongkol
Sasisopin Kiertiburanakul
Pamela A. Shaw
Jennifer L. Kirk
Kamonwan Jutivorakool
Rifat Zaman
Li Ding
Amy P. Hsu
Smita Y. Patel
Kenneth N. Olivier
Viraphong Lulitanond
Piroon Mootsikapun
Siriluck Anunnatsiri
Nasikarn Angkasekwinai
Boonmee Sathapatayavongs
Po Ren Hsueh
Chi Chang Shieh
Margaret R. Brown
Wanna Thongnoppakhun
Reginald Claypool
Elizabeth P. Sampaio
Charin Thepthai
Duangdao Waywa
Camilla Dacombe
Yona Reizes
Adrian M. Zelazny
Paul Saleeb
Lindsey B. Rosen
Allen Mo
Michael Iadarola
Steven M. Holland
National Institute of Allergy and Infectious Diseases
National Institute of Dental and Craniofacial Research
National Institutes of Health, Bethesda
Khon Kaen University
Mahidol University
Chulalongkorn University
University of Oxford
National Taiwan University
National Cheng Kung University
Fundacao Oswaldo Cruz
Colgate University
Keywords: Medicine
Issue Date: 23-Aug-2012
Citation: New England Journal of Medicine. Vol.367, No.8 (2012), 725-734
Abstract: BACKGROUND: Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence are unknown. METHODS: We enrolled 203 persons from sites in Thailand and Taiwan in five groups: 52 patients with disseminated, rapidly or slowly growing, nontuberculous mycobacterial infection (group 1); 45 patients with another opportunistic infection, with or without nontuberculous mycobacterial infection (group 2); 9 patients with disseminated tuberculosis (group 3); 49 patients with pulmonary tuberculosis (group 4); and 48 healthy controls (group 5). Clinical histories were recorded, and blood specimens were obtained. RESULTS: Patients in groups 1 and 2 had CD4+ T-lymphocyte counts that were similar to those in patients in groups 4 and 5, and they were not infected with the human immunodeficiency virus (HIV). Washed cells obtained from patients in groups 1 and 2 had intact cytokine production and a response to cytokine stimulation. In contrast, plasma obtained from these patients inhibited the activity of interferon-γ in normal cells. High-titer anti-interferon-γ autoantibodies were detected in 81% of patients in group 1, 96% of patients in group 2, 11% of patients in group 3, 2% of patients in group 4, and 2% of controls (group 5). Forty other anticytokine autoantibodies were assayed. One patient with cryptococcal meningitis had autoantibodies only against granulocyte-macrophage colony-stimulating factor. No other anticytokine autoantibodies or genetic defects correlated with infections. There was no familial clustering. CONCLUSIONS: Neutralizing anti-interferon-γ autoantibodies were detected in 88% of Asian adults with multiple opportunistic infections and were associated with an adult-onset immunodeficiency akin to that of advanced HIV infection. (Funded by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research; number, NCT00814827.) Copyright © 2012 Massachusetts Medical Society.
ISSN: 15334406
Appears in Collections:Scopus 2011-2015

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