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Title: Rectal pH in well and unwell infants
Authors: Claudia Turner
Naw Aye Mya Thein
Paul Turner
François Nosten
Nicholas J. White
Shoklo Malaria Research Unit
Mahidol University
University of Oxford
Keywords: Medicine
Issue Date: 1-Aug-2012
Citation: Journal of Tropical Pediatrics. Vol.58, No.4 (2012), 311-313
Abstract: Prompt antibiotic treatment for infants with sepsis has the potential to save lives. A rectal formulation of an antibiotic could be used at a village level before referral to hospital. The development of such a preparation needs to take into account the rectal pH of infants that will affect drug partitioning and absorption. Rectal pH measurements were taken in 100 well and 45 unwell infants. We also measured rectal pH in 14 infants sequentially over the course of their illness. The mean rectal pH was 6.75 with no significant difference in well or unwell infants. The mean (95% CI) rectal pH of well neonates was significantly lower than that of older infants ( > 28 days): 6.47 (6.29-6.65) vs. 6.90 (6.68 to 7.12) p = 0.003. © The Author [2011]. Published by Oxford University Press. All rights reserved.
ISSN: 14653664
Appears in Collections:Scopus 2011-2015

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