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Title: Normalized coagulation markers and anticoagulation proteins in children with severe β-thalassemia disease after stem cell transplantation
Authors: Nongnuch Sirachainan
Jaruwan Thongsad
Samart Pakakasama
Suradej Hongeng
Ampaiwan Chuansumrit
Praguywan Kadegasem
Arjit Tirakanjana
Napaporn Archararit
Somtawin Sirireung
Mahidol University
Keywords: Medicine
Issue Date: 1-Jun-2012
Citation: Thrombosis Research. Vol.129, No.6 (2012), 765-770
Abstract: The hypercoagulable state is well recognized in patients with severe β-thalassemia disease. One of the mechanisms of chronic hypercoagulable state is the abnormal expression of phosphatidylserine on red blood cells (RBC). This study aimed to determine the coagulable state in patients with severe β-thalassemia disease following successful stem cell transplantation (SCT). Subjects were classified into three groups: normal controls (NC), β-thalassemia disease receiving regular transfusion (Thal-RT) and β-thalassemia disease post SCT (Thal-SCT). Sixty eight subjects, aged 3-17 years, consisting of 21 NC, 28 Thal-RT and 19 Thal-SCT were enrolled. After SCT, the annexin V level in Thal-SCT was normalized. At the median follow-up time of 70.3 (50.9-84.2) months after SCT, the levels of coagulation markers (thrombin antithrombin complex, prothrombin fragment and D-dimer) and anticoagulation proteins (protein C, S and antithrombin activities) returned to the levels similar to controls. © 2011 Elsevier Ltd. All rights reserved.
ISSN: 18792472
Appears in Collections:Scopus 2011-2015

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