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Title: PSA density and prostate cancer detection
Authors: Armean Saema
Wachira Kochakarn
Panuwat Lertsithichai
Mahidol University
Keywords: Medicine
Issue Date: 1-May-2012
Citation: Journal of the Medical Association of Thailand. Vol.95, No.5 (2012), 661-666
Abstract: Objective: To evaluate the diagnostic value of prostate-specific antigen density (PSAD) and the appropriate cutoff for the detection of prostate cancer. Material and Method: Between January 2008 and March 2011, 292 men with PSA levels between 4 and 10 ng/mL underwent Transrectal Ultrasonography (TRUS) with prostate biopsy. The diagnostic value of PSA levels and PSAD were compared using receiver operating characteristic curves. Results: Prostate cancer was diagnosed in 64 (22%) of the 292 men who had PSA levels 4 to 10 ng/mL. The mean PSA level was 6.96 ng/mL. The mean age was 66 years. The area under the curve (AUC) of PSA and PSAD were 0.475 and 0.665, respectively. The sensitivity and specificity of PSAD at cutoff of 0.15 was 78% and 43%, respectively. Conclusion: PSAD was a better discriminator of prostate cancer than PSA for PSA levels less than 10 ng/ml. Our data suggested that a different PSAD cutoff than previously recommended need to be defined for Thai people.
ISSN: 01252208
Appears in Collections:Scopus 2011-2015

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