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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/14839
Title: The association between HLA class II alleles and the occurrence of factor VIII inhibitor in Thai patients with hemophilia A
Authors: Oytip Nathalang
Pramote Sriwanitchrak
Werasak Sasanakul
Ampaiwan Chuansumrit
Thammasat University
Mahidol University
Keywords: Medicine
Issue Date: 9-Apr-2012
Citation: Turkish Journal of Hematology. Vol.29, No.1 (2012), 34-39
Abstract: Objective: This study aimed to investigate the association between HLA class II alleles and the occurrence of FVIII inhibitor in Thai hemophilia A patients. Material and Methods: The distribution of HLA-DRB1 alleles and DQB1 alleles in 57 Thai hemophilia A patients and 36 blood donors as controls was determined using the PCR sequence-specific primer (PCR-SSP) method, and the association between the occurrence of factor VIII (FVIII) inhibitor and the presence of certain HLA class II alleles was investigated. Results: The frequency of HLA-DRB1z.ast;15 was higher in the hemophilia A patients with and without FVIII inhibitor, whereas that of DRB1z.ast;14, DRB1z.ast;07, and DQB1z.ast;02 was lower in the hemophilia A patients with FVIII inhibitor, as compared to controls. Interestingly, only the frequency of DRB1z.ast;15 was significantly higher in the patients with inhibitor than in the controls (P = 0.021). Moreover, the frequency of DRB1z.ast;15 in the patients with inhibitor was higher than in those without inhibitor (P = 0.198). Conclusion: The study's findings show that the DRB1z.ast;15 allele might have contributed to the occurrence of inhibitor in the Thai hemophilia A patients; however, additional research using larger samples and high-resolution DRB1 typing is warranted.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859364107&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/14839
ISSN: 13085263
13007777
Appears in Collections:Scopus 2011-2015

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