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Title: The role of postmortem studies in Pneumonia etiology research
Authors: Gareth D H Turner
Charatdao Bunthi
Chizoba B. Wonodi
Susan C. Morpeth
Catherine S. Molyneux
Sherif R. Zaki
Orin S. Levine
David R. Murdoch
J. Anthony G Scott
Mahidol University
Thailand Ministry of Public Health
Johns Hopkins Hospital
Wellcome Trust Research Laboratories Nairobi
Centers for Disease Control and Prevention
University of Otago
Canterbury Health Laboratories
Nuffield Department of Clinical Medicine
Keywords: Medicine
Issue Date: 1-Apr-2012
Citation: Clinical Infectious Diseases. Vol.54, No.SUPPL. 2 (2012)
Abstract: The diagnosis of etiology in severe pneumonia remains a challenging area. Postmortem lung tissue potentially increases the sensitivity of investigations for identification of causative pathogens in fatal cases of pneumonia and can confirm antemortem microbiological d iagnoses. Tissue sampling allows assessment of histological patterns of disease and ancillary immunohistochemical or molecular diagnostic techniques. It may also enhance the recognition of noninfectious conditions that clinically simulate acute pneumonia. Biobanking of lung tissue or postmortem culture isolates offers opportunities for new pathogen discovery and research into host-pathogen interactions. The Pneumonia Etiology Research for Child Health study proposes a percutaneous needle biopsy approach to obtain postmortem samples, rather than a full open autopsy. This has the advantage of greater acceptability to relatives, but risks greater sampling error. Both approaches may be susceptible to microbiological contamination or pathogen degradation. However, previous autopsy studies have confirmed the value of histological examination in revealing unsuspected pathogens and influencing clinical guidelines for the diagnosis and treatment of future pneumonia cases. © 2012 The Author.
ISSN: 15376591
Appears in Collections:Scopus 2011-2015

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