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dc.contributor.authorGareth D H Turneren_US
dc.contributor.authorCharatdao Bunthien_US
dc.contributor.authorChizoba B. Wonodien_US
dc.contributor.authorSusan C. Morpethen_US
dc.contributor.authorCatherine S. Molyneuxen_US
dc.contributor.authorSherif R. Zakien_US
dc.contributor.authorOrin S. Levineen_US
dc.contributor.authorDavid R. Murdochen_US
dc.contributor.authorJ. Anthony G Scotten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.contributor.otherJohns Hopkins Hospitalen_US
dc.contributor.otherWellcome Trust Research Laboratories Nairobien_US
dc.contributor.otherCenters for Disease Control and Preventionen_US
dc.contributor.otherUniversity of Otagoen_US
dc.contributor.otherCanterbury Health Laboratoriesen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.identifier.citationClinical Infectious Diseases. Vol.54, No.SUPPL. 2 (2012)en_US
dc.description.abstractThe diagnosis of etiology in severe pneumonia remains a challenging area. Postmortem lung tissue potentially increases the sensitivity of investigations for identification of causative pathogens in fatal cases of pneumonia and can confirm antemortem microbiological d iagnoses. Tissue sampling allows assessment of histological patterns of disease and ancillary immunohistochemical or molecular diagnostic techniques. It may also enhance the recognition of noninfectious conditions that clinically simulate acute pneumonia. Biobanking of lung tissue or postmortem culture isolates offers opportunities for new pathogen discovery and research into host-pathogen interactions. The Pneumonia Etiology Research for Child Health study proposes a percutaneous needle biopsy approach to obtain postmortem samples, rather than a full open autopsy. This has the advantage of greater acceptability to relatives, but risks greater sampling error. Both approaches may be susceptible to microbiological contamination or pathogen degradation. However, previous autopsy studies have confirmed the value of histological examination in revealing unsuspected pathogens and influencing clinical guidelines for the diagnosis and treatment of future pneumonia cases. © 2012 The Author.en_US
dc.rightsMahidol Universityen_US
dc.titleThe role of postmortem studies in Pneumonia etiology researchen_US
Appears in Collections:Scopus 2011-2015

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