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Title: Generation of gaseous sulfur-containing compounds in tumour tissue and suppression of gas diffusion as an antitumour treatment
Authors: Kazue Yamagishi
Kazuo Onuma
Yota Chiba
Shinya Yagi
Shigenobu Aoki
Tomoyuki Sato
Yasushi Sugawara
Noriyasu Hosoya
Yasutake Saeki
Minoru Takahashi
Masayoshi Fuji
Takeo Ohsaka
Takeyoshi Okajima
Kenji Akita
Takashi Suzuki
Pisol Senawongse
Akio Urushiyama
Kiyoshi Kawai
Hirofumi Shoun
Yoshimasa Ishii
Hiroya Ishikawa
Shigeru Sugiyama
Madoka Nakajima
Masaru Tsuboi
Tateo Yamanaka
FAP Dental Institute
Nagoya University
Gunma University
Saitama Shinkaibashi Clinic
Jichi Medical University
Tsurumi University
Nagoya Institute of Technology
Tokyo Institute of Technology
Nagoya Central Hospital
University of Yamanashi
Mahidol University
Rikkyo University
Shigakkan University
Graduate School of Agricultural and Life Sciences The University of Tokyo
Ebina General Hospital
Fukuoka Women's University
Osaka University
Bio-Safty Research Center
Keywords: Medicine
Issue Date: 1-Apr-2012
Citation: Gut. Vol.61, No.4 (2012), 554-561
Abstract: Background and aims: The mechanisms of cancer cell growth and metastasis are still not entirely understood, especially from the viewpoint of chemical reactions in tumours. Glycolytic metabolism is markedly accelerated in cancer cells, causing the accumulation of glucose (a reducing sugar) and methionine (an amino acid), which can non-enzymatically react and form carcinogenic substances. There is speculation that this reaction produces gaseous sulfur-containing compounds in tumour tissue. The aims of this study were to clarify the products in tumour and to investigate their effect on tumour proliferation. Methods: Products formed in the reaction between glucose and methionine or its metabolites were analysed in vitro using gas chromatography. Flatus samples from patients with colon cancer and exhaled air samples from patients with lung cancer were analysed using near-edge x-ray fine adsorption structure spectroscopy and compared with those from healthy individuals. The tumour proliferation rates of mice into which HT29 human colon cancer cells had been implanted were compared with those of mice in which the cancer cells were surrounded by sodium hyaluronate gel to prevent diffusion of gaseous material into the healthy cells. Results: Gaseous sulfur-containing compounds such as methanethiol and hydrogen sulfide were produced when glucose was allowed to react with methionine or its metabolites homocysteine or cysteine. Near-edge x-ray fine adsorption structure spectroscopy showed that the concentrations of sulfur-containing compounds in the samples of flatus from patients with colon cancer and in the samples of exhaled air from patients with lung cancer were significantly higher than in those from healthy individuals. Animal experiments showed that preventing the diffusion of sulfur-containing compounds had a pronounced antitumour effect. Conclusions: Gaseous sulfur-containing compounds are the main products in tumours and preventing the diffusion of these compounds reduces the tumour proliferation rate, which suggests the possibility of a new approach to cancer treatment.
ISSN: 14683288
Appears in Collections:Scopus 2011-2015

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