Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/14931
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRose Mcgreadyen_US
dc.contributor.authorAung Pyae Phyoen_US
dc.contributor.authorMarcus J. Rijkenen_US
dc.contributor.authorJoel Tarningen_US
dc.contributor.authorNiklas Lindegardhen_US
dc.contributor.authorWarunee Hanpithakponen_US
dc.contributor.authorHla Hla Thanen_US
dc.contributor.authorNathar Hlaingen_US
dc.contributor.authorNaw Thida Zinen_US
dc.contributor.authorPratap Singhasivanonen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorFrançois Nostenen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.date.accessioned2018-06-11T05:15:17Z-
dc.date.available2018-06-11T05:15:17Z-
dc.date.issued2012-03-01en_US
dc.identifier.citationBritish Journal of Clinical Pharmacology. Vol.73, No.3 (2012), 467-477en_US
dc.identifier.issn13652125en_US
dc.identifier.issn03065251en_US
dc.identifier.other2-s2.0-84857003505en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84857003505&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/14931-
dc.description.abstractAim: To determine if reported lower plasma concentrations of artemisinin derivatives for malaria in pregnancy result from reduced oral bioavailability, expanded volume of distribution or increased clearance. Methods: In a sequentially assigned crossover treatment study, pregnant women with uncomplicated falciparum malaria received i.v. artesunate (i.v. ARS) (4mgkg -1 ) on the first day and oral ARS (4mgkg -1 ) on the second, or, oral on the first and i.v. on the second, in both groups followed by oral ARS (4mgkg -1 day -1 ) for 5 days. Plasma concentrations of ARS and dihyroartemisinin (DHA) were measured by liquid chromatography-mass-spectrometry on days 0, 1, 2 and 6. Controls were the same women restudied when healthy (3 months post partum). Results: I.v. ARS administration resulted in similar ARS and DHA pharmacokinetics in pregnant women with malaria (n= 20) and in controls (n= 14). Oral administration resulted in higher total drug exposure in pregnancy [AUC (95% CI) in (ngml -1 h)/(mgkg -1 )] of 55.1 (30.1, 100.0) vs. 26.5 (12.2, 54.3) for ARS, P= 0.002 and 673 (386, 1130) vs. 523 (351, 724) for DHA, P= 0.007. The corresponding median absolute oral bioavailability (F%) was 21.7 (12.6, 75.1) vs. 9.9 (6.0, 36.81) for ARS (P= 0.046) and 77.0 (42.2, 129) vs. 72.7 (42.0, 87.7) for DHA, P= 0.033. Total DHA exposure was lower at day 6 in pregnant women with malaria (P < 0.001) compared with day 0 or 1, but not in the controls (P= 0.084). Conclusions: This study demonstrates the effects of malaria on oral ARS drug disposition are greater than those of pregnancy. This probably results from a disease related reduction in first pass metabolism. The data are reassuring regarding current dosing recommendations. © 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84857003505&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleArtesunate/dihydroartemisinin pharmacokinetics in acute falciparum malaria in pregnancy: Absorption, bioavailability, disposition and disease effectsen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1111/j.1365-2125.2011.04103.xen_US
Appears in Collections:Scopus 2011-2015

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.