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Title: Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: An Asian Network for Surveillance of Resistant Pathogens (ANSORP) study
Authors: So Hyun Kim
Jae Hoon Song
Doo Ryeon Chung
Visanu Thamlikitkul
Yonghong Yang
Hui Wang
Min Lu
Thomas Man Kit So
Po Ren Hsueh
Rohani M. Yasin
Celia C. Carlos
Hung Van Pham
M. K. Lalitha
Nobuyuki Shimono
Jennifer Perera
Atef M. Shibl
Jin Yang Baek
Cheol In Kang
Kwan Soo Ko
Kyong Ran Peck
Asia Pacific Foundation for Infectious Diseases (APFID)
SungKyunKwan University, School of Medicine
Mahidol University
Capital Medical University China
Peking Union Medical College
Shanghai Jiao Tong University
Princess Margaret Hospital Hong Kong
National Taiwan University Hospital
Institute for Medical Research Kuala Lumpur
University of Medicine and Pharmacy
Madras Medical Mission
Kyushu University Hospital
University of Colombo
King Saud University
Peking University
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Mar-2012
Citation: Antimicrobial Agents and Chemotherapy. Vol.56, No.3 (2012), 1418-1426
Abstract: Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Asian Network for Surveillance of Resistant Pathogens (ANSORP) performed a prospective surveillance study of 2,184 S. pneumoniae isolates collected from patients with pneumococcal infections from 60 hospitals in 11 Asian countries from 2008 to 2009. Among nonmeningeal isolates, the prevalence rate of penicillin- nonsusceptible pneumococci (MIC,≥4 μg/ml) was 4.6% and penicillin resistance (MIC,≥8 μg/ml) was extremely rare (0.7%). Resistance to erythromycin was very prevalent in the region (72.7%); the highest rates were in China (96.4%), Taiwan (84.9%), and Vietnam (80.7%). Multidrug resistance (MDR) was observed in 59.3% of isolates from Asian countries. Major serotypes were 19F (23.5%), 23F (10.0%), 19A (8.2%), 14 (7.3%), and 6B (7.3%). Overall, 52.5% of isolates showed PCV7 serotypes, ranging from 16.1% in Philippines to 75.1% in Vietnam. Serotypes 19A (8.2%), 3 (6.2%), and 6A (4.2%) were the most prominent non-PCV7 serotypes in the Asian region. Among isolates with serotype 19A, 86.0% and 79.8% showed erythromycin resistance and MDR, respectively. The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
ISSN: 10986596
Appears in Collections:Scopus 2011-2015

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