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dc.contributor.authorSo Hyun Kimen_US
dc.contributor.authorJae Hoon Songen_US
dc.contributor.authorDoo Ryeon Chungen_US
dc.contributor.authorVisanu Thamlikitkulen_US
dc.contributor.authorYonghong Yangen_US
dc.contributor.authorHui Wangen_US
dc.contributor.authorMin Luen_US
dc.contributor.authorThomas Man Kit Soen_US
dc.contributor.authorPo Ren Hsuehen_US
dc.contributor.authorRohani M. Yasinen_US
dc.contributor.authorCelia C. Carlosen_US
dc.contributor.authorHung Van Phamen_US
dc.contributor.authorM. K. Lalithaen_US
dc.contributor.authorNobuyuki Shimonoen_US
dc.contributor.authorJennifer Pereraen_US
dc.contributor.authorAtef M. Shiblen_US
dc.contributor.authorJin Yang Baeken_US
dc.contributor.authorCheol In Kangen_US
dc.contributor.authorKwan Soo Koen_US
dc.contributor.authorKyong Ran Pecken_US
dc.contributor.otherAsia Pacific Foundation for Infectious Diseases (APFID)en_US
dc.contributor.otherSungKyunKwan University, School of Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCapital Medical University Chinaen_US
dc.contributor.otherPeking Union Medical Collegeen_US
dc.contributor.otherShanghai Jiao Tong Universityen_US
dc.contributor.otherPrincess Margaret Hospital Hong Kongen_US
dc.contributor.otherNational Taiwan University Hospitalen_US
dc.contributor.otherInstitute for Medical Research Kuala Lumpuren_US
dc.contributor.otherUniversity of Medicine and Pharmacyen_US
dc.contributor.otherMadras Medical Missionen_US
dc.contributor.otherKyushu University Hospitalen_US
dc.contributor.otherUniversity of Colomboen_US
dc.contributor.otherKing Saud Universityen_US
dc.contributor.otherPeking Universityen_US
dc.identifier.citationAntimicrobial Agents and Chemotherapy. Vol.56, No.3 (2012), 1418-1426en_US
dc.description.abstractAntimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Asian Network for Surveillance of Resistant Pathogens (ANSORP) performed a prospective surveillance study of 2,184 S. pneumoniae isolates collected from patients with pneumococcal infections from 60 hospitals in 11 Asian countries from 2008 to 2009. Among nonmeningeal isolates, the prevalence rate of penicillin- nonsusceptible pneumococci (MIC,≥4 μg/ml) was 4.6% and penicillin resistance (MIC,≥8 μg/ml) was extremely rare (0.7%). Resistance to erythromycin was very prevalent in the region (72.7%); the highest rates were in China (96.4%), Taiwan (84.9%), and Vietnam (80.7%). Multidrug resistance (MDR) was observed in 59.3% of isolates from Asian countries. Major serotypes were 19F (23.5%), 23F (10.0%), 19A (8.2%), 14 (7.3%), and 6B (7.3%). Overall, 52.5% of isolates showed PCV7 serotypes, ranging from 16.1% in Philippines to 75.1% in Vietnam. Serotypes 19A (8.2%), 3 (6.2%), and 6A (4.2%) were the most prominent non-PCV7 serotypes in the Asian region. Among isolates with serotype 19A, 86.0% and 79.8% showed erythromycin resistance and MDR, respectively. The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A. Copyright © 2012, American Society for Microbiology. All Rights Reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleChanging trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: An Asian Network for Surveillance of Resistant Pathogens (ANSORP) studyen_US
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