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Title: α-secretase in Alzheimer's disease and beyond: Mechanistic, regulation and function in the shedding of membrane proteins
Authors: Bruno Vincent
Frédéric Checler
Universite Nice Sophia Antipolis
Mahidol University
Keywords: Medicine;Neuroscience
Issue Date: 1-Feb-2012
Citation: Current Alzheimer Research. Vol.9, No.2 (2012), 140-156
Abstract: Proteases regulate numerous physiological functions in all living organisms. Because of their contribution to βAPP processing, α-, β- and γ-secretases have focused particular attention of researchers in the field of Alzheimer's disease (AD) during the past 20 years. Whereas the β-secretase BACE1 and the heterotetrameric presenilin-dependent γ-secretase complex were identified between 1995 and 2002, α-secretase activity was attributed to previously described ADAM10 and ADAM17, two members of the type I integral membrane protein family called ADAMs (A Disintegrin And Metalloprotease). ADAM10 and/or ADAM17 target numerous substrates through various modes of action. This review focuses on the complex physiology of these α-secretases and will document their contribution to cancers, diabetes, rheumatoid arthritis, and prion diseases besides their well characterized role in Alzheimer's disease. © 2012 Bentham Science Publishers.
ISSN: 18755828
Appears in Collections:Scopus 2011-2015

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