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Title: Clinical indicators for pulmonary arterial hypertension in thalassemia
Authors: Nonlawan Chueamuangphan
Wattana Wongtheptien
Weerasak Nawarawong
Apichard Sukornthasarn
Suporn Chuncharunee
Chamaiporn Tawichasri
Jayanton Patumanond
Chiang Rai Prachanukhro Hospital
Chiang Mai University
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-2012
Citation: Journal of the Medical Association of Thailand. Vol.95, No.1 (2012), 16-21
Abstract: Objective: To explore clinical indicators for pulmonary arterial hypertension (PAH) in thalassemia (Thal). Material and Method: A study was conducted in thalassemia patients at Chiang Rai Hospital, Chiang Rai, Thailand. Pulmonary artery systolic pressure (PASP) was determined by doppler echocardiography and PAH was defined as PASP > 35 mmHg. Patient characteristics were extracted from medical records. Characteristics of patients with and without PAH were compared. Risk indicators were explored with logistic regression analysis. Results: Two hundred twenty four patients were included, 144 E/β-Thal, 37 homozygous β-Thal and 43 Hb H disease. There were 65 patients (29.0%) with PAH, 53 (81.5%) with E/β-Thal, 8 (12.3%) with homozygous β-Thal and 4 (6.2%) with Hb H disease. In a multivariable analysis, features significantly associated with PAH were E/β-Thal (OR = 1.98, 95% CI; 1.29-3.01) and post splenectomy status (OR = 2.36, 95% CI; 1.17-4.73). Conclusion: Significant indicators for PAH in thalassemia were E/β-Thal and post splenectomy status.
ISSN: 01252208
Appears in Collections:Scopus 2011-2015

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