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Title: Protective role of N-trans-feruloyltyramine against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons
Authors: Wipawan Thangnipon
Nirut Suwanna
Narisorn Kitiyanant
Rungtip Soi-ampornkul
Patoomratana Tuchinda
Bamroong Munyoo
Saksit Nobsathian
Mahidol University
Keywords: Neuroscience
Issue Date: 4-Apr-2012
Citation: Neuroscience Letters. Vol.513, No.2 (2012), 229-232
Abstract: Enhanced oxidative stress and inflammation play important roles in the pathogenesis of Alzheimer's disease (AD). Amyloid β-peptide (Aβ), a major component of amyloid plaques, is considered to have a causal role in the development and progress of AD by being the initiator of a pathological cascade leading to oxidative stress. The present study investigated the effect of N-trans-feruloyltyramine (NTF) purified from Polyalthia suberosa, an alkaloid shown to protect against oxidative stress and cell death. Pre-treatment of rat primary cortical cell cultures with 25-250μM NTF significantly attenuated 10μM Aβ 1-42 -induced neuronal death in a dose-dependent manner. Apoptotic cell death was demonstrated morphologically as well as by detection of the presence of activated caspase-3 and Bax, levels of which could be reduced by NTF pre-treatment. NTF also reduced production of reactive oxygen species induced by Aβ 1-42 . These findings suggest that the protective effect of NTF against Aβ 1-42 -induced neuronal death might be due to its antioxidative property. © 2012 Elsevier Ireland Ltd.
ISSN: 18727972
Appears in Collections:Scopus 2011-2015

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