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Title: Screening paediatric rectal forms of azithromycin as an alternative to oral or injectable treatment
Authors: Tina Kauss
Karen Gaudin
Alexandra Gaubert
Boubakar Ba
Serena Tagliaferri
Fawaz Fawaz
Jean Louis Fabre
Jean Michel Boiron
Xavier Lafarge
Nicholas J. White
Piero L. Olliaro
Pascal Millet
Developpements Analytiques et Pharmaceutiques Appliques aux Maladies Negligees et Aux Contrefacons
Accelera S.r.l.
OTECI (Office Technique d'Etude et de Coopération Internationale)
Etablissement Francais du Sang
Mahidol University
Nuffield Department of Clinical Medicine
Organisation Mondiale de la Sante
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 15-Oct-2012
Citation: International Journal of Pharmaceutics. Vol.436, No.1-2 (2012), 624-630
Abstract: The aim of this study was to identify a candidate formulation for further development of a home or near-home administrable paediatric rectal form of a broad-spectrum antibiotic - specially intended for (emergency) use in tropical rural settings, in particular for children who cannot take medications orally and far from health facilities where injectable treatments can be given. Azithromycin, a broad-spectrum macrolide used orally or intravenously for the treatment of respiratory tract, skin and soft tissue infections, was selected because of its pharmacokinetic and therapeutic properties. Azithromycin in vitro solubility and stability in physiologically relevant conditions were studied. Various pharmaceutical forms, i.e. rectal suspension, two different rectal gels, polyethylene glycol (PEG) suppository and hard gelatin capsule (HGC) were assessed for in vitro dissolution and in vivo bioavailability in the rabbit. Azithromycin PEG suppository appears to be a promising candidate. © 2012 Elsevier B.V. All rights reserved.
ISSN: 18733476
Appears in Collections:Scopus 2011-2015

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