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Title: Renal effects and injury induced by animal toxins
Authors: Visith Sitprija
Siravit Sitprija
Queen Saovabha Memorial Institute
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Oct-2012
Citation: Toxicon. Vol.60, No.5 (2012), 943-953
Abstract: Animal toxins are well recognized for their hazards to man. Consisting of peptides, enzymes, chemicals and proteins, animal toxins can cause cellular injury with a broad spectrum of clinical manifestations. The kidney, as a highly vascularized organ, is vulnerable to toxin injury by either hemodynamic alterations which lead to renal ischemia or by direct kidney injury. Hemodynamic changes can be induced by toxin effects on ion channels, or by peptides and enzymes. Hemodynamic changes, inflammatory and vasoactive mediators and direct nephrotoxicity are tightly intregrated in causing renal injury. Several animal toxin components are involved in renal injury. Effects of toxins on renal tubular epithelial transport, a rather neglected area, and serum electrolyte changes in the victims are brought to attention. © 2012 Elsevier Ltd.
ISSN: 18793150
Appears in Collections:Scopus 2011-2015

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