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Title: | DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata |
Authors: | Naowarat Kongkum Patoomratana Tuchinda Manat Pohmakotr Vichai Reutrakul Pawinee Piyachaturawat Surawat Jariyawat Kanoknetr Suksen Chalobon Yoosook Jitra Kasisit Chanita Napaswad Mahidol University |
Keywords: | Pharmacology, Toxicology and Pharmaceutics |
Issue Date: | 1-Mar-2012 |
Citation: | Fitoterapia. Vol.83, No.2 (2012), 368-372 |
Abstract: | Four new flavones, 5,2′-dihydroxy-7,3′,4′,5′- tetramethoxyflavone (1), 5,2′,5′-trihydroxy-7,3′,4′- trimethoxyflavone (2), 5,7,2′,5′-tetrahydroxy-6,3′,4′- trimethoxyflavone (3) and 5,2′,5′-trihydroxy-6,7,3′,4′- tetramethoxyflavone (4), along with the known 5,3′-dihydroxy-6,7,4′, 5′-tetramethoxyflavone (5), 5,7,3′,5′-tetrahydroxy-6,4′- dimethoxyflavone (6), syringaldehyde, vanillic acid and scopoletin were isolated from the leaves and twigs of Gardenia carinata (Rubiaceae). Their structures were determined by spectroscopic methods. Flavone 2 exhibited cytotoxic activity against P-388 and MCF-7 cell lines, while 3, 5 and 6 were active only in P-388 cell line. All active compounds were found to inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity. Flavones 1-3, 5 and 6 also exhibited anti-HIV-1 activity in the anti-syncytium assay using δTat/rev MC99 virus and 1A2 cell line system; 2 was most potent. Only flavones 1 and 6 showed considerably activity against HIV-1 reverse transcriptase. © 2011 Elsevier B.V. All rights reserve. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84855985112&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/15170 |
ISSN: | 18736971 0367326X |
Appears in Collections: | Scopus 2011-2015 |
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