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Title: Functionalized (poly(ε-caprolactone))<inf>2</inf>-poly(ethylene glycol) nanoparticles with grafting nicotinic acid as drug carriers
Authors: Jiraphong Suksiriworapong
Kittisak Sripha
Jörg Kreuter
Varaporn Buraphacheep Junyaprasert
Mahidol University
Goethe-Universitat Frankfurt am Main
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 28-Feb-2012
Citation: International Journal of Pharmaceutics. Vol.423, No.2 (2012), 562-570
Abstract: Nicotinic acid was grafted on (poly(ε-caprolactone)) 2 -poly(ethylene glycol) copolymers that were used for the preparation of nanoparticles with the objectives to monitor particle size and to optimize the drug loading capacity as well as the release profile of the particles. Increasing amounts of grafting nicotinic acid increased the particle size as a result of an enhanced hydrophobicity of the copolymer. Ibuprofen and indomethacin with two different molecular characteristics were selected as model drugs to be bound to the nanoparticles. The presence of grafting nicotinic acid enhanced the loading capacity for both drugs compared to the nanoparticles without nicotinic acid. However, no correlation between amount of grafting nicotinic acid and loading capacity was observed. The release characteristic of both d rugs was fitted to the Higuchi model indicating Fickian diffusion. The release characteristic of indomethacin mainly depended on the crystalline property of the copolymer whereas that of ibuprofen was additionally influenced by the hydrogen bonding between drug and grafted copolymer. © 2011 Elsevier B.V. All rights reserved.
ISSN: 18733476
Appears in Collections:Scopus 2011-2015

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