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dc.contributor.authorNitchaphat Khansakornen_US
dc.contributor.authorWaranya Wongwiten_US
dc.contributor.authorPrapin Tharnpoophasiamen_US
dc.contributor.authorBunlue Hengprasithen_US
dc.contributor.authorLerson Suwannathonen_US
dc.contributor.authorSuwannee Chanprasertyothinen_US
dc.contributor.authorThunyachai Suraen_US
dc.contributor.authorSming Kaojarernen_US
dc.contributor.authorPiyamit Sritaraen_US
dc.contributor.authorJintana Sirivarasaien_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherElectricity Generating Authority of Thailanden_US
dc.identifier.citationJournal of Toxicology. Vol.2012, (2012)en_US
dc.description.abstractThe glutathione S-transferases (GSTs) are involved in biotransformation and detoxification of cadmium (Cd). Genetic polymorphisms in these genes may lead to interindividual variation in Cd susceptibility. The objective of this study was to assess the association of GSTs (GSTT1, GSTM1, and GSTP1 Val105Ile) polymorphisms with blood Cd concentrations in a nonoccupationally exposed population. The 370 blood samples were analyzed for Cd concentration and polymorphisms in GSTs genes. Geometric mean of blood Cd among this population was 0.46 ± 0.02 g/L (with 95% CI; 0.43-0.49g/L). Blood Cd concentrations in subjects carrying GSTP1 Val/Val genotype were significantly higher than those with Ile/Ile and Ile/Val genotypes. No significant differences in blood Cd concentrations among individual with gene deletions of GSTT1 and GSTM1 were observed. GSTP1/GSTT1 and GSTP1/GSTM1 combinations showed significantly associated with increase in blood Cd levels. This study indicated that polymorphisms of GSTP1 combined with GSTT1 and/or GSTM1 deletion are likely to influence on individual susceptibility to cadmium toxicity. © 2012 Nitchaphat Khansakorn et al.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleGenetic variations of glutathione S-transferase influence on blood cadmium concentrationen_US
Appears in Collections:Scopus 2011-2015

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