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dc.contributor.authorMagnus Manskeen_US
dc.contributor.authorOlivo Miottoen_US
dc.contributor.authorSusana Campinoen_US
dc.contributor.authorSarah Auburnen_US
dc.contributor.authorJacob Almagro-Garciaen_US
dc.contributor.authorGareth Maslenen_US
dc.contributor.authorJack O'Brienen_US
dc.contributor.authorAbdoulaye Djimdeen_US
dc.contributor.authorOgobara Doumboen_US
dc.contributor.authorIssaka Zongoen_US
dc.contributor.authorJean Bosco Ouedraogoen_US
dc.contributor.authorPascal Michonen_US
dc.contributor.authorIvo Muelleren_US
dc.contributor.authorPeter Sibaen_US
dc.contributor.authorAlexis Nzilaen_US
dc.contributor.authorSteffen Borrmannen_US
dc.contributor.authorSteven M. Kiaraen_US
dc.contributor.authorKevin Marshen_US
dc.contributor.authorHongying Jiangen_US
dc.contributor.authorXin Zhuan Suen_US
dc.contributor.authorChanaki Amaratungaen_US
dc.contributor.authorRick Fairhursten_US
dc.contributor.authorDuong Socheaten_US
dc.contributor.authorFrancois Nostenen_US
dc.contributor.authorMallika Imwongen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorMandy Sandersen_US
dc.contributor.authorElisa Anastasien_US
dc.contributor.authorDan Alcocken_US
dc.contributor.authorEleanor Druryen_US
dc.contributor.authorSamuel Oyolaen_US
dc.contributor.authorMichael A. Quailen_US
dc.contributor.authorDaniel J. Turneren_US
dc.contributor.authorValentin Ruano-Rubioen_US
dc.contributor.authorDushyanth Jyothien_US
dc.contributor.authorLucas Amenga-Etegoen_US
dc.contributor.authorChristina Hubbarten_US
dc.contributor.authorAnna Jeffreysen_US
dc.contributor.authorKate Rowlandsen_US
dc.contributor.authorColin Sutherlanden_US
dc.contributor.authorCally Roperen_US
dc.contributor.authorValentina Manganoen_US
dc.contributor.authorDavid Modianoen_US
dc.contributor.authorJohn C. Tanen_US
dc.contributor.authorMichael T. Ferdigen_US
dc.contributor.authorAlfred Amambua-Ngwaen_US
dc.contributor.authorDavid J. Conwayen_US
dc.contributor.authorShannon Takala-Harrisonen_US
dc.contributor.authorChristopher V. Ploween_US
dc.contributor.authorJulian C. Rayneren_US
dc.contributor.authorKirk A. Rocketten_US
dc.contributor.authorTaane G. Clarken_US
dc.contributor.authorChris I. Newbolden_US
dc.contributor.authorMatthew Berrimanen_US
dc.contributor.authorBronwyn MacInnisen_US
dc.contributor.authorDominic P. Kwiatkowskien_US
dc.contributor.otherWellcome Trust Sanger Instituteen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherMenzies School of Health Researchen_US
dc.contributor.otherWellcome Trust Centre for Human Geneticsen_US
dc.contributor.otherUniversity of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatologyen_US
dc.contributor.otherInstitut de Recherche en Sciences de la Santéen_US
dc.contributor.otherPapua New Guinea Institute of Medical Researchen_US
dc.contributor.otherWellcome Trust Research Laboratories Nairobien_US
dc.contributor.otherNational Institute of Allergy and Infectious Diseasesen_US
dc.contributor.otherCambodia National Malaria Centreen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherNavrongo Health Centreen_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherUniversita degli Studi di Roma La Sapienzaen_US
dc.contributor.otherUniversity of Notre Dameen_US
dc.contributor.otherMedical Research Council Laboratories Gambiaen_US
dc.contributor.otherUniversity of Maryland, Baltimoreen_US
dc.contributor.otherWeatherall Institute of Molecular Medicineen_US
dc.date.accessioned2018-06-11T05:27:39Z-
dc.date.available2018-06-11T05:27:39Z-
dc.date.issued2012-07-19en_US
dc.identifier.citationNature. Vol.487, No.7407 (2012), 375-379en_US
dc.identifier.issn14764687en_US
dc.identifier.issn00280836en_US
dc.identifier.other2-s2.0-84863982076en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863982076&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/15243-
dc.description.abstractMalaria elimination strategies require surveillance of the parasite population for genetic changes that demand a public health response, such as new forms of drug resistance. Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture. Analysis of 86,158 exonic single nucleotide polymorphisms that passed genotyping quality control in 227 samples from Africa, Asia and Oceania provides genome-wide estimates of allele frequency distribution, population structure and linkage disequilibrium. By comparing the genetic diversity of individual infections with that of the local parasite population, we derive a metric of within-host diversity that is related to the level of inbreeding in the population. An open-access web application has been established for the exploration of regional differences in allele frequency and of highly differentiated loci in the P.falciparum genome. © 2012 Macmillan Publishers Limited. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863982076&origin=inwarden_US
dc.subjectMultidisciplinaryen_US
dc.titleAnalysis of Plasmodium falciparum diversity in natural infections by deep sequencingen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1038/nature11174en_US
Appears in Collections:Scopus 2011-2015

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