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Title: A major genome region underlying artemisinin resistance in malaria
Authors: Ian H. Cheeseman
Becky A. Miller
Shalini Nair
Standwell Nkhoma
Asako Tan
John C. Tan
Salma Al Saai
Aung Pyae Phyo
Carit Ler Moo
Khin Maung Lwin
Rose McGready
Elizabeth Ashley
Mallika Imwong
Kasia Stepniewska
Poravuth Yi
Arjen M. Dondorp
Mayfong Mayxay
Paul N. Newton
Nicholas J. White
Fran├žois Nosten
Michael T. Ferdig
Timothy J.C. Anderson
Texas Biomedical Research Institute
University of Notre Dame
Shoklo Malaria Research Unit
Mahidol University
Churchill Hospital
Mahosot Hospital
WorldWide Antimalarial Resistance Network
National Center for Parasitology, Entomology and Malaria Control
Keywords: Multidisciplinary
Issue Date: 6-Apr-2012
Citation: Science. Vol.335, No.6077 (2012), 79-82
Abstract: Evolving resistance to artemisinin-based compounds threatens to derail attempts to control malaria. Resistance has been confirmed in western Cambodia and has recently emerged in western Thailand, but is absent from neighboring Laos. Artemisinin resistance results in reduced parasite clearance rates (CRs) after treatment. We used a two-phase strategy to identify genome region(s) underlying this ongoing selective event. Geographical differentiation and haplotype structure at 6969 polymorphic single-nucleotide polymorphisms (SNPs) in 91 parasites from Cambodia, Thailand, and Laos identified 33 genome regions under strong selection. We screened SNPs and microsatellites within these regions in 715 parasites from Thailand, identifying a selective sweep on chromosome 13 that shows strong association (P = 10 -6 to 10 -12 ) with slow CRs, illustrating the efficacy of targeted association for identifying the genetic basis of adaptive traits.
ISSN: 10959203
Appears in Collections:Scopus 2011-2015

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