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dc.contributor.authorIan H. Cheesemanen_US
dc.contributor.authorBecky A. Milleren_US
dc.contributor.authorShalini Nairen_US
dc.contributor.authorStandwell Nkhomaen_US
dc.contributor.authorAsako Tanen_US
dc.contributor.authorJohn C. Tanen_US
dc.contributor.authorSalma Al Saaien_US
dc.contributor.authorAung Pyae Phyoen_US
dc.contributor.authorCarit Ler Mooen_US
dc.contributor.authorKhin Maung Lwinen_US
dc.contributor.authorRose McGreadyen_US
dc.contributor.authorElizabeth Ashleyen_US
dc.contributor.authorMallika Imwongen_US
dc.contributor.authorKasia Stepniewskaen_US
dc.contributor.authorPoravuth Yien_US
dc.contributor.authorArjen M. Dondorpen_US
dc.contributor.authorMayfong Mayxayen_US
dc.contributor.authorPaul N. Newtonen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorFran├žois Nostenen_US
dc.contributor.authorMichael T. Ferdigen_US
dc.contributor.authorTimothy J.C. Andersonen_US
dc.contributor.otherTexas Biomedical Research Instituteen_US
dc.contributor.otherUniversity of Notre Dameen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChurchill Hospitalen_US
dc.contributor.otherMahosot Hospitalen_US
dc.contributor.otherWorldWide Antimalarial Resistance Networken_US
dc.contributor.otherNational Center for Parasitology, Entomology and Malaria Controlen_US
dc.identifier.citationScience. Vol.335, No.6077 (2012), 79-82en_US
dc.description.abstractEvolving resistance to artemisinin-based compounds threatens to derail attempts to control malaria. Resistance has been confirmed in western Cambodia and has recently emerged in western Thailand, but is absent from neighboring Laos. Artemisinin resistance results in reduced parasite clearance rates (CRs) after treatment. We used a two-phase strategy to identify genome region(s) underlying this ongoing selective event. Geographical differentiation and haplotype structure at 6969 polymorphic single-nucleotide polymorphisms (SNPs) in 91 parasites from Cambodia, Thailand, and Laos identified 33 genome regions under strong selection. We screened SNPs and microsatellites within these regions in 715 parasites from Thailand, identifying a selective sweep on chromosome 13 that shows strong association (P = 10 -6 to 10 -12 ) with slow CRs, illustrating the efficacy of targeted association for identifying the genetic basis of adaptive traits.en_US
dc.rightsMahidol Universityen_US
dc.titleA major genome region underlying artemisinin resistance in malariaen_US
Appears in Collections:Scopus 2011-2015

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