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Title: Platelet function tests in thalassemic children.
Authors: P. Isarangkura
P. Pintadit
P. Hathirat
W. Sasanakul
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Dec-1987
Citation: Birth defects original article series. Vol.23, No.5 A (1987), 395-401
Abstract: Platelet changes in thalassemia included prolongation of bleeding time (30%), thrombocytosis (29%), decreased platelet retention (79%), and normal PF3 release. Platelet aggregation was found to be hyperaggregation in 50%, normal in 22%, and hypoaggregation in 28% of the studied patients. Platelet changes in thalassemia can be hyper-, normal, or hypofunction. The changes are likely to be related to many factors, particularly to the progress of the disease. Platelet hypoaggregation may lead to a bleeding problem. Platelet hyperaggregation and thrombocytosis were prominent in the splenectomized patients and/or the severely anemic group; antiplatelet drugs may be indicated in these patients.
ISSN: 05476844
Appears in Collections:Scopus 1969-1990

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