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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/15309
Title: Synaptosomal neurotransmitter uptake systems in the retina and brain nuclei of light- and dark-adapted rabbits
Authors: Thyon Chentanez
Dianna A. Redburn
Mahidol University
University of Texas Medical School at Houston
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine;Neuroscience
Issue Date: 20-Oct-1987
Citation: Brain Research. Vol.424, No.1 (1987), 115-118
Abstract: High affinity uptake rate for [ 14 C]aspartate and [ 3 H]dopamine by retinal homogenate (H), P 1 (outer plexiform layer, OPL), and P 2 (inner plexiform layer, IPL) retinal synaptosomal fractions were not significantly different between light- and dark-adapted rabbits. However, there were significant increases in the dark in [ 3 H]γ-aminobutyric acid high affinity uptake rate by retinal H and P 2 but not that of P 1 . There was a significantly higher [ 3 H]choline uptake rate by retinal H, P 1 and P 2 in the dark-adapted compared to light-adapted rabbits, but there was no significant change in this rate for synaptosomal fractions from the lateral geniculate body, superior colliculus, visual cortex (VA I + II), caudate nucleus (CN) and hippocampus (HP). Data obtained in this study, along with reports of others, indicate that the change in retinal neurotransmission functions may not always be parallel with the change in high affinity uptake rates of neurotransmitters by retinal synaptosomal fractions. Data obtained indicate an increase in retinal cholinergic neuronal activities in the dark and indicate that optic nerves are not cholinergic and cholinergic neurons in brain nuclei, such as VA, CN and HP, are not significantly influenced by optic nerve inputs in light and dark conditions. © 1987.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023567973&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/15309
ISSN: 00068993
Appears in Collections:Scopus 1969-1990

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