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dc.contributor.authorYongyuth Yuthavongen_US
dc.contributor.authorTemduang Limpaiboonen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationBBA - Molecular Cell Research. Vol.929, No.3 (1987), 278-287en_US
dc.description.abstractMembrane from Plasmodium berghei-infected mouse erythrocytes showed a pattern of protein phosphorylation which was substantially altered from the normal pattern, with an increase in the phosphorylation of the protein with an apparent molecular weight of 43 000 (M 43), which increased from undetectable in uninfected cells to a maximum in the mature trophozoite stage. Phosphorylation levels of this and other minor bands were strongly correlated with osmotic fragility and filterability. The level of M 43 phosphorylation in membranes from cells which remained intact in a hypotonic medium was 3.82 ± 0.59-times that of lysed cells, compared with the value of 0.76 ± 0.07 calculated from distribution alone. Results found when intact erythrocytes were phosphorylated by incubation with [ 32 P]P i prior to partial lysis were similar to those found when membranes from the lysed and unlysed fractions were subsequently phosphorylated with [γ- 32 P]ATP. Infected erythrocytes which could pass repeatedly through 3-μm polycarbonate filters had a much higher phosphorylation level for the M 43 region than whole infected cells with similar parasitemia and stage distribution. The phosphorylation change could play a role in the control of osmotic and mechanical properties of the infected erythrocytes during maturation. © 1987.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleThe relationship of phosphorylation of membrane proteins with the osmotic fragility and filterability of Plasmodium berghei-infected mouse erythrocytesen_US
Appears in Collections:Scopus 1969-1990

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