Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorT. Harinasutaen_US
dc.contributor.authorD. Bunnagen_US
dc.contributor.authorS. Vanijanonden_US
dc.contributor.authorP. Charoenlarpen_US
dc.contributor.authorP. Suntharasmaien_US
dc.contributor.authorS. Chitamasen_US
dc.contributor.authorU. K. Shethen_US
dc.contributor.authorW. H. Wernsdorferen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationBulletin of the World Health Organization. Vol.65, No.3 (1987), 363-367en_US
dc.description.abstractA total of 89 adult male Thai patients who had acute, uncomplicated falciparum malaria were treated in a double-blind randomized trial with a single oral dose of two or three tablets, each consisting of 250 mg mefloquine, 500 mg sulfadoxine, and 25 mg pyrimethamine (MSP). The two-tablet regimen produced a cure rate (S response) of 93%, the three-tablet regimen a cure rate of 98%. The mean duration of parasitaemia for the two- and three-tablet groups was 29 hours, respectively, while the mean duration of fever was 43 and 40 hours, respectively. Differences between the groups were not statistically significant. Tolerance was good at both dose levels. The main side-effects were abdominal discomfort, nausea, vomiting, dizziness, and diarrhoea, but these were mild, transient, and required no specific treatment. The results of haematological and biochemical investigations and of urinalysis revealed no drug-related changes following administration of MSP. The electrocardiograms of some patients revealed sinus bradycardia or sinus arrythmia, but these conditions were transient, symptomless, and clinically not significant.en_US
dc.rightsMahidol Universityen_US
dc.titleMefloquine, sulfadoxine, and pyrimethamine in the treatment of symptomatic falciparum malaria: A double-blind trial for determining the most effective doseen_US
Appears in Collections:Scopus 1969-1990

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.