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Title: Different molecular defects of <sup>G</sup>γ (<sup>A</sup>γδβ)°‐thalassaemia in Thailand
Authors: S. Fucharoen
P. Winichagoon
S. Chaicharoen
P. Wasi
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-1987
Citation: European Journal of Haematology. Vol.39, No.2 (1987), 154-160
Abstract: DNA from members of 2 Thai families with conditions considered to be δβ‐thalassaemia were studied by using restriction endonuclease DNA mapping. The propositus in family A is a double heterozygote for β‐thalassaemia and δβ‐thalassaemia. DNA analysis reveals a deletion of the β‐globin gene cluster starting at the area between the Sac I and Eco RI sites near the 3′ end of the G γ‐gene and extending through the A γ‐, δ‐ and β‐genes to an unknown extent downstream. In family B, the propositus is δβ‐thalassaemia/Hb E. Deletion of the β‐globin gene cluster begins in the large intervening sequence of the A γ‐gene and removes both δ‐ and β‐genes downstream. © Munksgaard 1987
ISSN: 16000609
Appears in Collections:Scopus 1969-1990

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