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Title: βthalassemia associated with αthalassemia in Thailand
Authors: S. Fucharoen
P. Winichagoon
V. Thonglairum
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-1988
Citation: Hemoglobin. Vol.12, No.5-6 (1988), 581-592
Abstract: In Thailand αthalassemia (thal), βthal, hemoglobin (Hb) E and Hb Constant Spring (Hb CS) are prevalent. The incidences are 20-30% for αthal (3.5% for αthal-1 and 16% for αthal-2), 3-9% for βthal, up to 54% for Hb E and nearly 8% for Hb CS (1). Different combinations of these genes result in a spectrum of thalassemia syndromes ranging in severity from asymptomatic to intrauterine death. From the known gene frequencies the numbers of thalassemic patients per generation (total population of 50 million) are as follows: Hb Bart's hydrops fetalis 20,000; homozygous βthal 31,250; βthallHb E disease 162,500; Hb H disease (two genotypes) 200,000, making a total of 413,750. In addition, individuals may carry more than two of the abnormal genes leading to complex thalassemia syndromes such as αbeta;thal, AE-Bart's and EF-Bart's diseases. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
ISSN: 03630269
Appears in Collections:Scopus 1969-1990

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