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Title: Effects of temperature, humidity, and aging on the disintegration and dissolution of acetaminophen tablets
Authors: Narong Sarisuta
Eugene L. Parrott
Mahidol University
University of Iowa
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1988
Citation: Drug Development and Industrial Pharmacy. Vol.14, No.13 (1988), 1877-1881
Abstract: The effect of storage for 8 weeks at 40°C in moderate and high humidity on acetaminophen tablets prepared by the wet granulation method using povidone or pregelatinized starch as a binder was studies. Storage at 52% relative humidity produced an increase in hardness of acetaminophen tablets and storage at 94% relative humidity caused a decrease in hardness. In all cases tablets granulated with pregelatinized starch were less susceptible to change caused by humidity than tablets granulated with povidone. The disintegration of tablets containing starch or povidone was slowed as the humidity was increased. Tablets stored at 40 =C and 94 V. relative humidity showed a substantial slowing of dissolution, but there was little change of dissolution of tablets when aged at 40 -C / 52% relative humidity. In comparing starch and povidone as binders, acetaminophen tablets prepared with pregelatinized starch were less effected by high humidity than tablets prepared with povidone. © 1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
ISSN: 03639045
Appears in Collections:Scopus 1969-1990

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