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Title: Dengue-4 vaccine: Neurovirulence, viraemia and immune responses in rhesus and cynomolgus monkeys
Authors: Subhkij Angsubhakorn
Sutee Yoksan
Natth Bhamarapravati
James B. Moe
Nyven J. Marchette
Apichat Pradermwong
Somphong Sahaphong
Department of Pathobiology
Mahidol University
Pfizer Inc.
University of Hawaii System
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1988
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.82, No.5 (1988), 746-749
Abstract: A dengue 4 (DEN-4, strain 1036-PDK 48) vaccine attenuated by passage in primary dog kidney cells was tested using rhesus (Macaca mulatto) and cynomolgus (M. fascicularis) monkeys to determine its safety, potency, and immunogenicity. 14 rhesus monkeys were divided into 3 groups: group 1, 2 animals given control culture fluid; group 2, 2 animals given DEN-4 parental virus; group 3, 10 animals given DEN-4 vaccine virus. 10 cynomolgus were similarly grouped, but group 3 contained 6 monkeys. No significant neurovirulence was observed with parental or with DEN-4 virus passaged in primary dog kidney (PDK) cells. Both cynomolgus monkeys inoculated with DEN-4 vaccine virus developed minimal (V-l) and mild (V-2) neurovirulence-type lesions in the central nervous system, which were nondestructive in both species. All parental and vaccine viruses produced moderate to high neutralizing antibody titres. Only parental virus produced viraemia, in 2 cynomolgus monkeys. Because of its safety and avirulence in monkeys, PDK 48 is recommended for human trial. © Royal Society of Tropical Medicine and Hygiene.
ISSN: 18783503
Appears in Collections:Scopus 1969-1990

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