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dc.contributor.authorJ. Karbwangen_US
dc.contributor.authorD. J. Backen_US
dc.contributor.authorD. Bunnagen_US
dc.contributor.authorA. M. Breckenridgeen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Liverpoolen_US
dc.identifier.citationEuropean Journal of Clinical Pharmacology. Vol.35, No.6 (1988), 677-680en_US
dc.description.abstractWe have studied the kinetics of a single oral dose of mefloquine (750 mg) in 12 Thai patients with falciparum malaria and have compared the results with those of a previous study in 12 healthy Thai volunteers [6]. All the patients responded to treatment with a mean parasite clearance time of 66.6 h and a mean fever clearance time of 54.1 h. There was no significant difference in peak plasma concentration, time to peak, area under the curve or apparent volume of distribution between patients and controls. However, the terminal half-life (t 1/2 ) and mean residence time (MRT) were shorter in the patients (12.2 vs 16.7 days for t 1/2 and 15.5 vs 21.4 days for MRT). We conclude that there are changes in the disposition of mefloquine related to malaria, although the exact basis of the changes is not clear. © 1988 Springer-Verlag.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleA comparison of the pharmacokinetics of mefloquine in healthy Thai volunteers and in Thai patients with falciparum malariaen_US
Appears in Collections:Scopus 1969-1990

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