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Title: Hematologic changes in α-thalassemia
Authors: S. Fucharoen
V. Thonglairuam
P. Winichagoon
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-1988
Citation: American Journal of Clinical Pathology. Vol.90, No.2 (1988), 193-196
Abstract: Alpha-thalassemia is very common in Thailand. Interaction of the different types of α-thalassemia can lead to many α-thalassemia syndromes. In this study the authors compare the hematologic data of subjects with various α-thalassemia phenotypes. Designation of the genotypes was based on family study and DNA mapping. The results show that there are equivocal hematologic findings among those who have similar molecular defects i.e., α-thalassemia-2 and hemoglobin (Hb) Constant Spring heterozygotes: α-thalassemia 1, homozygous α-thalassemia 2, and α-thalassemia 2/Hb Constant Spring. The severity of these α-thalassemia syndromes correlates with the α-globin gene expression calculated from the finding of Liebhaber.
ISSN: 00029173
Appears in Collections:Scopus 1969-1990

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