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Title: Clinical importance of antimalarial pharmacokinetics
Authors: J. Karbwang
N. J. White
Mahidol University
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1988
Citation: Asia Pacific Journal of Pharmacology. Vol.3, No.3 (1988), 181-189
Abstract: The efficacy of an antimalarial drug depends on its specific inhibitory or cidal activity on a given species and strain of a malaria parasite. It also depends on pharmacokinetic considerations such as the speed of absorption, concentration of drug in plasma or in infected erythrocytes, distribution in tissues, clearance by metabolism and renal elimination and pharmacodynamic considerations such as toxicity. Recommendations on dosage regimens for antimalaria treatment and prophylaxis should be based on pharmacokinetic and pharmacodynamic studies performed in appropriate populations (i.e. both in volunteers and in children, adults and pregnant women with both uncomplicated and severe malaria).
ISSN: 02179687
Appears in Collections:Scopus 1969-1990

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