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|Title:||Detection of β-thalassemia and hemoglobin E genes in Thai by a DNA amplification technique|
|Keywords:||Biochemistry, Genetics and Molecular Biology;Medicine|
|Citation:||Human Genetics. Vol.82, No.4 (1989), 389-390|
|Abstract:||Enzymatic DNA amplification and polyacrylamide gel electrophoresis, which demonstrate different sizes of DNA fragments, were used to detect the common mutations causing β-thalassemia and hemoglobin (Hb) E in Thai people. The 4-bp deletion at codons 41 and 42 can be detected directly by polyacrylamide gel electrophoresis and ethidium bromide staining. Whereas the nonsense mutations at codon 17 (AAG →TAG) and Hb E (GAG→AAG at codon 26) were detected after digestion of the amplified DNA with the enzymes MaeI and MnlI, respectively. © 1989 Springer-Verlag.|
|Appears in Collections:||Scopus 1969-1990|
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