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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/15710
Title: Mitochondria as the site of action of tetracycline on Plasmodium falciparum
Authors: Rachada Kiatfuengfoo
Tuangporn Suthiphongchai
Phisit Prapunwattana
Yongyuth Yuthavong
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-May-1989
Citation: Molecular and Biochemical Parasitology. Vol.34, No.2 (1989), 109-115
Abstract: Rhodamine 123 (Rh 123) was used as a fluorescent probe for the mitochondria of the malarial parasite Plasmodium falciparum. On treatment with tetracycline in vitro, a marked decrease in the percentage of parasites with Rh123 fluorescence in the mitochondria was observed in parallel with an increase in the percentage of parasites with abnormal morphology during onset of decrease in parasitemia. Similar results were obtained, over a shorter time period, with 2,4-dinitrophenol. However, the percentage of parasites with fluorescence did not decrease with increase in parasite abnormal morphology or decrease in parasitemia on treatment with pyrimethamine or cycloheximide. Isoelectric focusing-SDS gel electrophoresis of radiolabelled parasite proteins showed two components of 95 and 85 kDa, the synthesis of which was sensitive to tetracycline, but not cycloheximide. It is concluded that tetracycline exerts its action through the effect on parasite mitochondria and mitochondrial protein synthesis. © 1989.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024544052&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/15710
ISSN: 01666851
Appears in Collections:Scopus 1969-1990

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