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Title: Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors
Authors: H. Stalsberg
D. B. Thomas
E. A. Noonan
G. Berry
R. Maclennan
R. Shearman
T. Jelihovsky
J. Cooper Booth
R. Molina
L. Martinez
O. Salas
A. Dabancens
Chen Zhiheng
Tao Yun
Hu Yong Wei
A. Cuadros
N. Aristizabal
K. Ebeling
P. Nishan
D. Kunde
B. Modan
E. Ron
E. Alfandary
J. G. Mati
P. Kenya
A. Kungu
D. Gatei
H. Rodriguez Cuevas
S. Benavides Salazar
A. Palet
P. Ontiveros
R. A. Apelo
J. R.La De Cruz
J. Baens
B. Javier
Suporn Silpisornkosol
Tieng Pardthaisong
Nimit Martin
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrichanalai
Prasarn Jimakorn
Suporn Koetsawang
Daungdao Rachawat
Nivat Chantarakul
S. Holck
Universitetet i Tromso
Fred Hutchinson Cancer Research Center
The University of Sydney
Facultad de Medicina de la Universidad de Chile
Shanghai Institute of Planned Parenthood Research
Hospital Universitario
Academy of Sciences
Chaim Sheba Medical Center Israel
University of Nairobi
Hospital General de Mexico
University of the Philippines Manila
Chiang Mai University
Chulalongkorn University
Mahidol University
Organisation Mondiale de la Sante
Development and Research Training in Human Reproduction
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-1989
Citation: International Journal of Cancer. Vol.44, No.3 (1989), 399-409
Abstract: Associations between breast cancer risk factors and histologic types of invasive breast carcinoma were studied in 2,728 patients. Lobular and tubular carcinomas occurred with increased relative frequency in most high‐risk groups. The proportion of these types increased with age to a maximum at 45–49 years and decreased in the following decade. Significantly increased proportions of lobular and tubular carcinomas were also associated with high‐risk countries, prior benign breast biopsy, bilateral breast cancer, concurrent mammary dysplasia, high age at first live birth, never‐pregnant patients compared to those with a first live birth before age 20, private pay status, and length of education. Nonsignificant increases were associated with family history of breast cancer, less than 5 live births, less than 25 months total of breast feeding, use of oral contraceptives or IUD, and high occupational class. As a general trend, the higher the overall relative risk, the higher the proportion of lobular and tubular carcinomas. The occurrence of other histologic types also increased with increased breast cancer risk, but to a smaller degree than for lobular/tubular carcinomas. It is suggested that all hormonally related, socio‐economic and geographic risk factors exert their effect by selectively increasing the number of lobular cells at risk. Family history of breast cancer and age over 49 years did not follow the general trend of parallel increases in the proportion of lobular/tubular carcinomas and breast cancer risk, and may operate through other mechanisms. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company
ISSN: 10970215
Appears in Collections:Scopus 1969-1990

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