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dc.contributor.authorUte Mackenstedten_US
dc.contributor.authorHeinz Mehlhornen_US
dc.contributor.authorChariya R. Brockelmanen_US
dc.contributor.otherRuhr-Universitat Bochumen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationZentralblatt fur Bakteriologie. Vol.271, No.3 (1989), 356-363en_US
dc.description.abstractβ-thalassemic erythrocytes and normal red blood cells were experimentally infected in vitro with Plasmodium falciparum cultured for 4 days and studied by means of transmission electron microscopy. Conspicuous alterations of the parasites appear in the advanced stage of schizogony leading to the fact that only a small amount of malaria pigment is formed, which in general is not crystalline, but always enclosed in extremely large vacuoles. Furthermore some of the developing merozoites reveal features of cellular degeneration, thus these merozoites lost their ability to invade new erythrocytes. Despite these findings alterations of the host cells are induced by the parasites, which, however, are comparable to those found in infected normal red blood cells, e.g. knobs appeared on the surface of the erythrocytes and membrane-bounded clefts became apparent in the cytoplasm of the host cell. © 1989, Gustav Fischer Verlag, Stuttgart · New York. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleUltrastructural Study on the Interaction of β-Tha1assemicErythrocytes and Plasmodium falciparumen_US
Appears in Collections:Scopus 1969-1990

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