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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/15778
Title: OPEN COMPARISON OF INTRAMUSCULAR CHLOROQUINE AND QUININE IN CHILDREN WITH SEVERE CHLOROQUINE-SENSITIVE FALCIPARUM MALARIA
Authors: N. J. White
D. Waller
D. Kwiatkowski
S. Krishna
C. Craddock
D. Brewster
Mahidol University
Nuffield Department of Clinical Medicine
Imperial College Faculty of Medicine
Medical Research Council Laboratories Gambia
Royal Victoria Teaching Hospital Gambia
Keywords: Medicine
Issue Date: 2-Dec-1989
Citation: The Lancet. Vol.334, No.8675 (1989), 1313-1316
Abstract: An open paired randomised comparison of intramuscular chloroquine (3·5 mg base/kg every 6 h) and intramuscular quinine (20 mg salt/kg followed by 10 mg/kg every 12 h) was carried out in 50 Gambian children with severe falciparum malaria. 8 children died, 6 from the quinine-treated and 2 from the chloroquine-treated group. Chloroquine reduced parasitaemia significantly more rapidly than did quinine, but other measures of the therapeutic response were similar in the two groups. Quinine injections were painful. These findings do not support the proposition that quinine is intrinsically superior to chloroquine in the treatment of severe drug-sensitive falciparum malaria. © 1989.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024369347&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/15778
ISSN: 01406736
Appears in Collections:Scopus 1969-1990

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