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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/15795
Title: HALVING OF MORTALITY OF SEVERE MELIOIDOSIS BY CEFTAZIDIME
Authors: N. J. White
W. Chaowagul
V. Wuthiekanun
D. A.B. DANCE
Y. Wattanagoon
N. Pitakwatchara
Mahidol University
Nuffield Department of Clinical Medicine
Sappasitthiprasong Hospital
Keywords: Medicine
Issue Date: 23-Sep-1989
Citation: The Lancet. Vol.334, No.8665 (1989), 697-701
Abstract: An open randomised trial was conducted to compare ceftazidime (120 mg/kg/day) with "conventional therapy" (chloramphenicol 100 mg/kg/day, doxycycline 4 mg/kg/day, trimethoprim 10 mg/kg/day, and sulphamethoxazole 50 mg/kg/day) in the treatment of severe melioidosis. A paired restricted sequential trial designed to detect a reduction in mortality from 80 to 40% in culture-positive patients surviving > 48 hours was stopped after 22 months. Of the 161 patients entered into the study, 65 had bacteriologically confirmed melioidosis and 54 of these were septicaemic. Ceftazidime treatment was associated with a 50% (95% CI 19-81%) lower overall mortality than conventional treatment (74% vs 37%; p=0·009) and should now become the treatment of choice for severe melioidosis. © 1989.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024449456&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/15795
ISSN: 01406736
Appears in Collections:Scopus 1969-1990

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