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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/15804
Title: Interactions in vitro between agents used to treat melioidosis
Authors: D. A.B. Dance
V. Wuthiekanun
W. Chaowagul
N. J. White
Mahidol University
John Radcliffe Hospital
Sappasitthiprasong Hospital
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Sep-1989
Citation: Journal of Antimicrobial Chemotherapy. Vol.24, No.3 (1989), 311-316
Abstract: Combinations of antimicrobial agents are usually recommended for the treatment of melioidosis. In Thailand, the conventional treatment regimen for Pseudomonas pseudomallei infections is a combination of chloramphenicol, doxycycline and cotrimoxazole. We have consistently observed antagonism between these agents during routine disc susceptibility testing. Interactions between these antimicrobials were studied further by a chequerboard microdilution method, using five clinical isolates of P. pseudomallei. Both trimethoprim and sulphamethoxazole antagonised the bacteriostatic activity of chloramphenicol and doxycycline. The combination of trimethoprim and sulphamethoxazole was synergistic, but not bactericidal. Bacteriostatic drugs antagonised the bactericidal activity of ceftazidime, which is undergoing clinical trials in severe melioidosis. These findings may be of therapeutic relevance. © 1989 by The British Society for Antimicrobial Chemotherapy.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024457146&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/15804
ISSN: 03057453
Appears in Collections:Scopus 1969-1990

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