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Title: Human pythiosis associated with thalassemia hemoglobinopathy syndrome
Authors: Boonmee Sathapatayavongs
Paisan Leelachaikul
Roongnapa Prachaktam
Vichai Atichartakarn
Suthus Sriphojanart
Prasert Trairatvorakul
Sopon Jirasiritham
Suwattana Nontasut
Charindr Eurvilaichit
Timothy Flegel
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-1989
Citation: Journal of Infectious Diseases. Vol.159, No.2 (1989), 274-280
Abstract: Pythium infection (pythiosis) in humans has not previously been described, even in areas endemic for animal pythiosis. We report five patients with a unique presentation of fungal arteritis. The medium- to large-sized arteries were involved, and in some cases this involvement led to gangrene of the limbs, aneurysm formation, and ultimately fatal arterial leakage. All five patients were farmers. All patients, with the possible exception of one who had hemoglobin typing performed after receiving a blood transfusion, had thalassemia hemoglobinopathy syndrome. Fungal isolation was difficult. Amphotericin B treatment seemed to be ineffective. Radical surgical removal of infected tissues and oral administration of a saturated solution of potassium iodide are proposed therapy. In the tropics, where Pythium is ubiquitous, one should actively look for this fungal infection in patients with unexplained arterial occlusion, especially in the case of patients with thalassemia hemoglobinopathy syndrome. © 1989, by The University of Chicago. All Rights Reserved.
ISSN: 15376613
Appears in Collections:Scopus 1969-1990

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